Crossing barriers: infections of the lung and the gut | Zendy

Peter Openshaw | Zendy

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Crossing barriers: infections of the lung and the gut

Author(s) -

Peter Openshaw

Publication year - 2009

Publication title -

mucosal immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.596

H-Index - 101

eISSN - 1935-3456

pISSN - 1933-0219

DOI - 10.1038/mi.2008.79

Subject(s) - bacterial translocation , lung , immunology , respiratory system , microbiology and biotechnology , medicine , chromosomal translocation , biology , biochemistry , gene

Although known as respiratory pathogens, severe acute respiratory syndrome (SARS) and its sister coronaviruses frequently cause enteric symptoms. In addition, other classically non-enteric viruses (such as HIV and influenza) may also have enteric effects that are crucial in their pathogeneses. These effects can be due to direct infection of the gut mucosa, but can also be because of decreased antibacterial defenses, increased mucosal permeability, bacterial translocation, and systemic leak of endotoxin.

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