Innate immune recognition of the indigenous microbial flora | Zendy

Seth Rakoff-Nahoum | Zendy; Ruslan Medzhitov | Zendy

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Innate immune recognition of the indigenous microbial flora

Author(s) -

Seth Rakoff-Nahoum,

Ruslan Medzhitov

Publication year - 2008

Publication title -

mucosal immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.596

H-Index - 101

eISSN - 1935-3456

pISSN - 1933-0219

DOI - 10.1038/mi.2008.49

Subject(s) - innate immune system , flora (microbiology) , pattern recognition receptor , indigenous , context (archaeology) , biology , immune system , immunology , receptor , function (biology) , toll , microbiology and biotechnology , bacteria , ecology , genetics , paleontology

Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development.

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