Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia | Zendy

Francisco FernándezKlett | Zendy; Josef Priller | Zendy

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Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia

Author(s) -

Francisco FernándezKlett,

Josef Priller

Publication year - 2015

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2015.60

Subject(s) - ischemia , cerebral blood flow , neurovascular bundle , mural cell , pericyte , microcirculation , neuroscience , hemodynamics , blood flow , medicine , pathology , biology , cardiology , endothelial stem cell , vascular smooth muscle , smooth muscle , in vitro , biochemistry

Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity (‘functional hyperemia’). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue. The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.

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