Metabolic Connectivity as Index of Verbal Working Memory | Zendy

Na Zou | Zendy; Gaël Chételat | Zendy; Mustafa Gökçe Baydoğan | Zendy; Jing Li | Zendy; Florian U. Fischer | Zendy; Dmitry Titov | Zendy; Juergen Dukart | Zendy; Andreas Fellgiebel | Zendy; Mathias Schreckenberger | Zendy; Igor Yakushev | Zendy

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Metabolic Connectivity as Index of Verbal Working Memory

Author(s) -

Na Zou,

Gaël Chételat,

Mustafa Gökçe Baydoğan,

Jing Li,

Florian U. Fischer,

Dmitry Titov,

Juergen Dukart,

Andreas Fellgiebel,

Mathias Schreckenberger,

Igor Yakushev

Publication year - 2015

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2015.40

Subject(s) - positron emission tomography , working memory , psychology , verbal memory , cognition , audiology , nuclear medicine , neuroscience , medicine

Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.

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