Noninvasive High-Speed Photoacoustic Tomography of Cerebral Hemodynamics in Awake-Moving Rats | Zendy

Jianbo Tang | Zendy; Lei Xi | Zendy; Junli Zhou | Zendy; Hua Huang | Zendy; Tao Zhang | Zendy; Paul R. Carney | Zendy; Huabei Jiang | Zendy

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Noninvasive High-Speed Photoacoustic Tomography of Cerebral Hemodynamics in Awake-Moving Rats

Author(s) -

Jianbo Tang,

Lei Xi,

Junli Zhou,

Hua Huang,

Tao Zhang,

Paul R. Carney,

Huabei Jiang

Publication year - 2015

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2015.138

Subject(s) - hemodynamics , photoacoustic imaging in biomedicine , medicine , anesthesia , cerebral blood volume , haemodynamic response , blood volume , photoacoustic tomography , wakefulness , in vivo , biomedical engineering , tomography , blood pressure , heart rate , radiology , electroencephalography , biology , physics , optics , microbiology and biotechnology , psychiatry

We present a noninvasive method of photoacoustic tomography (PAT) for imaging cerebral hemodynamics in awake-moving rats. The wearable PAT (wPAT) system has a size of 15 mm in height and 33 mm in diameter, and a weight of ~8 g (excluding cabling). The wPAT achieved an imaging rate of 3.33 frames/s with a lateral resolution of 243 μm. Animal experiments were designed to show wPAT feasibility for imaging cerebral hemodynamics on awake-moving animals. Results showed that the cerebral oxy-hemoglobin and deoxy-hemoglobin changed significantly in response to hyperoxia; and, after the injection of pentylenetetrazol (PTZ), cerebral blood volume changed faster over time and larger in amplitude for rats in awake-moving state compared with rats under anesthesia. By providing a light-weight, high-resolution technology for in vivo monitoring of cerebral hemodynamics in awake-behaving animals, it will be possible to develop a comprehensive understanding on how activity alters hemodynamics in normal and diseased states.

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