Frizzled Fissure to Improve Central Nervous System Drug Delivery? | Zendy

Lester R. Drewes | Zendy

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Frizzled Fissure to Improve Central Nervous System Drug Delivery?

Author(s) -

Lester R. Drewes

Publication year - 2014

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2014.98

Subject(s) - wnt signaling pathway , efflux , frizzled , paracellular transport , p glycoprotein , drug delivery , central nervous system , transcellular , pharmacology , downregulation and upregulation , microbiology and biotechnology , signal transduction , transporter , neuroscience , biology , medicine , chemistry , drug resistance , biochemistry , organic chemistry , membrane , multiple drug resistance , gene , permeability (electromagnetism)

Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.

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