Unexpected Complication in a Rat Stroke Model: Exacerbation of Secondary Pathology in the Thalamus by Subacute Intraarterial Administration of Human Bone Marrow-Derived Mesenchymal Stem Cells | Zendy

Bhimashankar Mitkari | Zendy; Erja Kerkelä | Zendy; Johanystedt | Zendy; Matti Korhonen | Zendy; Jukka Jolkkonen | Zendy

Open Access

Unexpected Complication in a Rat Stroke Model: Exacerbation of Secondary Pathology in the Thalamus by Subacute Intraarterial Administration of Human Bone Marrow-Derived Mesenchymal Stem Cells

Author(s) -

Bhimashankar Mitkari,

Erja Kerkelä,

Johanystedt,

Matti Korhonen,

Jukka Jolkkonen

Publication year - 2015

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2014.235

Subject(s) - thalamus , mesenchymal stem cell , medicine , pathology , bone marrow , ischemia , stromal cell , complication , stroke (engine) , radiology , mechanical engineering , engineering

This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.

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