Functional MRI in Mice Lacking IP3-Dependent Calcium Signaling in Astrocytes | Zendy

Pierrick Jégo | Zendy; Jesús PachecoTorres | Zendy; Alfonso Araque | Zendy; Santiago Canals | Zendy

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Functional MRI in Mice Lacking IP₃-Dependent Calcium Signaling in Astrocytes

Author(s) -

Pierrick Jégo,

Jesús PachecoTorres,

Alfonso Araque,

Santiago Canals

Publication year - 2014

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2014.144

Subject(s) - neuroscience , functional magnetic resonance imaging , calcium signaling , calcium imaging , calcium , electrophysiology , cytosol , astrocyte , biology , signal transduction , chemistry , microbiology and biotechnology , central nervous system , biochemistry , enzyme , organic chemistry

Functional magnetic resonance imaging (fMRI) is a fundamental tool to investigate human brain networks. However, the cellular mechanisms underlying fMRI signals are not fully understood. One hypothetical mechanism is the putative vascular control exerted by cytosolic calcium in perivascular astrocytes. We have performed combined fMRI-electrophysiology experiments in mice lacking the inositol 1,4,5-triphosphate-type-2 receptor, with the primary pathway of cytosolic calcium increase eliminated into astrocytes. Our results show that evoked electrophysiologic activity and fMRI signals acquired during either transient or sustained neuronal activations occur independently of these large calcium signals. This result challenges the suggested intermediary role of astrocytic calcium surges in fMRI-signal generation.

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