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It has been proposed that prostaglandin E 2  (PGE 2 ) is released from astrocytic endfeet to dilate parenchymal arterioles through activation of prostanoid (EP 4 ) receptors during neurovascular coupling. However, the direct effects of PGE 2  on isolated parenchymal arterioles have not been tested. Here, we examined the effects of PGE 2  on the diameter of isolated pressurized parenchymal arterioles from rat and mouse brain. Contrary to the prevailing assumption, we found that PGE 2  (0.1, 1, and 5 μmol/L) constricted rather than dilated parenchymal arterioles. Vasoconstriction to PGE 2  was prevented by inhibitors of EP 1  receptors. These results strongly argue against a direct role of PGE 2  on arterioles during neurovascular coupling.

Prostaglandin E2, a Postulated Astrocyte-Derived Neurovascular Coupling Agent, Constricts Rather than Dilates Parenchymal Arterioles

Prostaglandin E₂, a Postulated Astrocyte-Derived Neurovascular Coupling Agent, Constricts Rather than Dilates Parenchymal Arterioles