Microglia is an Active Player in How Glibenclamide Improves Stroke Outcome
Author(s) -
Francisco J. Ortega,
Jukka Jolkkonen,
Manuel J. Rodrı́guez
Publication year - 2013
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.2013.72
Subject(s) - glibenclamide , microglia , sulfonylurea receptor , medicine , ischemia , potassium channel , neuroscience , blockade , pharmacology , stroke (engine) , receptor , inflammation , endocrinology , biology , diabetes mellitus , mechanical engineering , engineering
The recent review article"Sulfonylurea receptor 1 in central nervous system injury: a focused review"1 is an extensive summary of the current knowledge of the role of the sulfonylurea receptor 1 (SUR-1) and SUR-1-regulated NCCa-ATP channels in acute brain injuries. The review also highlights the potential translational applicability of the use of glibenclamide in treating brain pathologies such as cerebral ischemia or traumatic brain injury
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