Non-Invasive Measurement of Cerebral Oxygen Metabolism in the Mouse Brain by Ultra-High Field 17O MR Spectroscopy | Zendy

Weina Cui | Zendy; XiaoHong Zhu | Zendy; Manda L. Vollmers | Zendy; Emily T Colonna | Zendy; Gregor Adriany | Zendy; Brandon Tramm | Zendy; Janet M. Dubinsky | Zendy; Gülin Öz | Zendy

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Non-Invasive Measurement of Cerebral Oxygen Metabolism in the Mouse Brain by Ultra-High Field ¹⁷O MR Spectroscopy

Author(s) -

Weina Cui,

XiaoHong Zhu,

Manda L. Vollmers,

Emily T Colonna,

Gregor Adriany,

Brandon Tramm,

Janet M. Dubinsky,

Gülin Öz

Publication year - 2013

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2013.172

Subject(s) - oxygen , oxygen metabolism , brain function , oxygen delivery , functional magnetic resonance spectroscopy of the brain , in vivo magnetic resonance spectroscopy , neuroscience , chemistry , magnetic resonance imaging , medicine , biology , functional magnetic resonance imaging , organic chemistry , radiology

To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust, efficient, and practical method for quantification of cerebral oxygen consumption is needed. (17)O magnetic resonance spectroscopy (MRS) has been validated to measure cerebral metabolic rate of oxygen (CMRO2) in the rat brain; however, mice present unique challenges because of their small size. We show that CMRO2 measurements with (17)O MRS in the mouse brain are highly reproducible using 16.4 Tesla and a newly designed oxygen delivery system. The method can be utilized to measure mitochondrial function in mice quickly and repeatedly, without oral intubation, and has numerous potential applications to study cerebral energetics.

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