Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging | Zendy

Sadia Butt | Zendy; Lise Vejby Søgaard | Zendy; Peter Magnusson | Zendy; M. Lauritzen | Zendy; Christoffer Laustsen | Zendy; Per Åkeson | Zendy; Jan Henrik ArdenkjærLarsen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized ¹³C Magnetic Resonance Spectroscopic Imaging

Author(s) -

Sadia Butt,

Lise Vejby Søgaard,

Peter Magnusson,

M. Lauritzen,

Christoffer Laustsen,

Per Åkeson,

Jan Henrik ArdenkjærLarsen

Publication year - 2012

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2012.34

Subject(s) - metabolism , magnetic resonance imaging , chemistry , glutamate receptor , nuclear magnetic resonance , leucine , amino acid , biochemistry , medicine , physics , receptor , radiology

The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1- 13 C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1- 13 C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research