English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Cerebral hypoxia and acidosis can follow traumatic brain injury (TBI) and are associated with increased mortality. This study aimed to evaluate a relationship between reduced pH bt  and disturbances of cerebral metabolism. Prospective data from 56 patients with TBI, receiving microdialysis and Neurotrend monitoring, were analyzed. Four tissue states were defined based on pH bt  and P bt O 2 : 1—low P bt O 2 /pH bt , 2—low pH bt /normal P bt O 2 , 3—normal pH bt /low P bt O 2 , and 4—normal pH bt /P bt O 2 ). Microdialysis values were compared between the groups. The relationship between P bt O 2  and lactate/pyruvate (LP) ratio was evaluated at different pH bt  levels. Proportional contribution of each state was evaluated against mortality. As compared with the state 4, the state 3 was not different, the state 2 exhibited higher levels of lactate, LP, and glucose and the state 1—higher LP and reduced glucose ( P &lt; 0.001). A significant negative correlation between LP and P bt O 2  (rho = −0.159, P &lt; 0.001) was stronger at low pH bt  (rho = −0.201, P &lt; 0.001) and nonsignificant at normal pH bt  ( P = 0.993). The state 2 was a significant discriminator of mortality categories ( P = 0.031). Decreased pH bt  is associated with impaired metabolism. Measuring pH bt  with P bt O 2  is a more robust way of detecting metabolic derangements.

Extracellular Brain Ph with or without Hypoxia is a Marker of Profound Metabolic Derangement and Increased Mortality after Traumatic Brain Injury