Crossed Cerebellar Diaschisis: Insights into Oxygen Challenge MRI | Zendy

Krishna Dani | Zendy; Celestine Santosh | Zendy; David Brennan | Zendy; Donald M. Hadley | Zendy; Keith W. Muir | Zendy

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Crossed Cerebellar Diaschisis: Insights into Oxygen Challenge MRI

Author(s) -

Krishna Dani,

Celestine Santosh,

David Brennan,

Donald M. Hadley,

Keith W. Muir

Publication year - 2012

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2012.142

Subject(s) - diaschisis , cerebellum , magnetic resonance imaging , neuroscience , hyperoxia , cerebral blood volume , functional magnetic resonance imaging , medicine , blood oxygen level dependent , psychology , radiology , lung

Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.

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