Validation and Quantification of [18F]Altanserin Binding in the Rat Brain Using Blood Input and Reference Tissue Modeling | Zendy

Patrick J. Riss | Zendy; Young T. Hong | Zendy; David J. Williamson | Zendy; Daniele Caprioli | Zendy; Sergey Sitnikov | Zendy; Valentina Ferrari | Zendy; Stephen J. Sawiak | Zendy; JeanClaude Baron | Zendy; Jeffrey W. Dalley | Zendy; Tim D. Fryer | Zendy; Franklin I. Aigbirhio | Zendy

Open Access

Validation and Quantification of [¹⁸F]Altanserin Binding in the Rat Brain Using Blood Input and Reference Tissue Modeling

Author(s) -

Patrick J. Riss,

Young T. Hong,

David J. Williamson,

Daniele Caprioli,

Sergey Sitnikov,

Valentina Ferrari,

Stephen J. Sawiak,

JeanClaude Baron,

Jeffrey W. Dalley,

Tim D. Fryer,

Franklin I. Aigbirhio

Publication year - 2011

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2011.94

Subject(s) - positron emission tomography , metabolite , brain tissue , cerebellum , chemistry , tissue distribution , distribution (mathematics) , medicine , endocrinology , nuclear medicine , biology , biochemistry , mathematics , mathematical analysis

The 5-hydroxytryptamine type 2a (5-HT(2A)) selective radiotracer [(18)F]altanserin has been subjected to a quantitative micro-positron emission tomography study in Lister Hooded rats. Metabolite-corrected plasma input modeling was compared with reference tissue modeling using the cerebellum as reference tissue. [(18)F]altanserin showed sufficient brain uptake in a distribution pattern consistent with the known distribution of 5-HT(2A) receptors. Full binding saturation and displacement was documented, and no significant uptake of radioactive metabolites was detected in the brain. Blood input as well as reference tissue models were equally appropriate to describe the radiotracer kinetics. [(18)F]altanserin is suitable for quantification of 5-HT(2A) receptor availability in rats.

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