Moderate Or Deep Local Hypothermia Does Not Prevent the Onset of Ischemia-Induced Dendritic Damage | Zendy

Sherri Tran | Zendy; XingQiu Chen | Zendy; Ran R. Liu | Zendy; Yicheng Xie | Zendy; Timothy H. Murphy | Zendy

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Moderate Or Deep Local Hypothermia Does Not Prevent the Onset of Ischemia-Induced Dendritic Damage

Author(s) -

Sherri Tran,

XingQiu Chen,

Ran R. Liu,

Yicheng Xie,

Timothy H. Murphy

Publication year - 2011

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2011.178

Subject(s) - hypothermia , ischemia , medicine , in vivo , dendritic spine , brain damage , anesthesia , brain ischemia , neuroscience , biology , hippocampal formation , microbiology and biotechnology

We studied the acute (up to 2 hours after reperfusion) effects of localized cortical hypothermia on ischemia-induced dendritic structural damage. Moderate (31°C) and deep (22°C) hypothermia delays, but does not block the onset of dendritic blebbing or spine loss during global ischemia in mouse in vivo. Hypothermic treatment promoted more consistent recovery of dendritic structure and spines during reperfusion. These results suggest that those using therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but hypothermia may interact with mechanisms that control the onset of damage and recovery during reperfusion.

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