Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury | Zendy

Amy E.B. Packard | Zendy; Jason C. Hedges | Zendy; Frances Rena Bahjat | Zendy; Susan L. Stevens | Zendy; Michael J. Conlin | Zendy; Andres Μ. Salazar | Zendy; Mary P. StenzelPoore | Zendy

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Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury

Author(s) -

Amy E.B. Packard,

Jason C. Hedges,

Frances Rena Bahjat,

Susan L. Stevens,

Michael J. Conlin,

Andres Μ. Salazar,

Mary P. StenzelPoore

Publication year - 2011

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2011.160

Subject(s) - ischemia , medicine , ischemic preconditioning , pharmacology , in vivo , inflammation , reperfusion injury , anesthesia , cardiology , immunology , biology , microbiology and biotechnology

Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.

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