Laser Speckle Contrast Imaging of Collateral Blood Flow during Acute Ischemic Stroke | Zendy

Glenn A Armitage | Zendy; Kathryn G. Todd | Zendy; Ashfaq Shuaib | Zendy; Ian R. Winship | Zendy

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Laser Speckle Contrast Imaging of Collateral Blood Flow during Acute Ischemic Stroke

Author(s) -

Glenn A Armitage,

Kathryn G. Todd,

Ashfaq Shuaib,

Ian R. Winship

Publication year - 2010

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2010.73

Subject(s) - collateralization , medicine , blood flow , collateral circulation , cardiology , occlusion , speckle pattern , middle cerebral artery , ischemia , stroke (engine) , cerebral blood flow , ischemic stroke , collateral , computer science , mechanical engineering , finance , artificial intelligence , economics , engineering

Collateral vasculature may provide an alternative route for blood flow to reach the ischemic tissue and partially maintain oxygen and nutrient support during ischemic stroke. However, much about the dynamics of stroke-induced collateralization remains unknown. In this study, we used laser speckle contrast imaging to map dynamic changes in collateral blood flow after middle cerebral artery occlusion in rats. We identified extensive anastomatic connections between the anterior and middle cerebral arteries that develop after vessel occlusion and persist for 24 hours. Augmenting blood flow through these persistent yet dynamic anastomatic connections may be an important but relatively unexplored avenue in stroke therapy.

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