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Calcium-sensitive potassium (K Ca ) channels have been shown to modulate the diameter of cerebral pial arteries; however, little is known regarding their roles in controlling cerebral parenchymal arterioles (PAs). We explored the function and cellular distribution of small-conductance (SK Ca ) and intermediate-conductance (IK Ca ) K Ca  channels and large-conductance K Ca  (BK Ca ) channels in endothelial cells (ECs) and smooth muscle cells (SMCs) of PAs. Both SK Ca  and IK Ca  channels conducted the outward current in isolated PA ECs (current densities, ~20 pA/pF and ~28 pA/pF at + 40 mV, respectively), but these currents were not detected in PA SMCs. In contrast, BK Ca  currents were prominent in PA SMCs (~ 154pA/pF), but were undetectable in PA ECs. Pressurized PAs constricted to inhibition of SK Ca  (~ 16%) and IK Ca  (~ 16%) channels, but were only modestly affected by inhibition of BK Ca  channels (~ 5%). Blockade of SK Ca  and IK Ca  channels decreased resting cortical cerebral blood flow (CBF) by ~ 15%. NS309 (6,7-dichloro-1H-indole-2,3-dione3-oxime), a SK Ca /IK Ca  channel opener, hyperpolarized PA SMCs by ~ 27 mV, maximally dilated pressurized PAs, and increased CBF by ~ 40%. In conclusion, these data show that SK Ca  and IK Ca  channels in ECs profoundly modulate PA tone and CBF, whereas BK Ca  channels in SMCs only modestly influence PA diameter.

Endothelial SKCa and IKCa Channels Regulate Brain Parenchymal Arteriolar Diameter and Cortical Cerebral Blood Flow

Endothelial SK_Ca and IK_Ca Channels Regulate Brain Parenchymal Arteriolar Diameter and Cortical Cerebral Blood Flow