Brain Glutamine Synthesis Requires Neuronal Aspartate: A Commentary | Zendy

Leif Hertz | Zendy

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Brain Glutamine Synthesis Requires Neuronal Aspartate: A Commentary

Author(s) -

Leif Hertz

Publication year - 2010

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2010.199

Subject(s) - transamination , glutamate receptor , glutamine , cytosol , biochemistry , glutamate aspartate transporter , glutamate synthase , citrate synthase , chemistry , biology , amino acid , glutamine synthetase , enzyme , excitatory amino acid transporter , receptor

Inspired by the paper, 'Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation' by Pardo et al, a modified model of oxidation-reduction, transamination, and mitochondrial carrier reactions involved in aspartate-dependent astrocytic glutamine synthesis and oxidation is proposed. The alternative model retains the need for cytosolic aspartate for transamination of α-ketoglutarate, but the 'missing' aspartate molecule is generated within astrocytes during subsequent glutamate oxidation. Oxaloacetate formed during glutamate formation is used during glutamate degradation, and all transmitochondrial reactions, oxidations-reductions, and cytosolic and mitochondrial transaminations are stoichiometrically balanced. The model is consistent with experimental observations made by Pardo et al.

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