Determination of the Brain–Blood Partition Coefficient for Water in Mice Using MRI | Zendy

Christoph Leithner | Zendy; Susanne Müller | Zendy; Martina Füchtemeier | Zendy; Ute Lindauer | Zendy; Ulrich Dirnagl | Zendy; Georg Royl | Zendy

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Determination of the Brain–Blood Partition Coefficient for Water in Mice Using MRI

Author(s) -

Christoph Leithner,

Susanne Müller,

Martina Füchtemeier,

Ute Lindauer,

Ulrich Dirnagl,

Georg Royl

Publication year - 2010

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2010.160

Subject(s) - cerebral blood flow , coefficient of variation , magnetic resonance imaging , partition coefficient , stroke (engine) , chemistry , nuclear magnetic resonance , biomedical engineering , nuclear medicine , medicine , chromatography , anesthesia , radiology , physics , thermodynamics

Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89 ± 0.03 mL/g, with little regional variation within the mouse brain.

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