Predictive Value of Platelet Activation for the Rate of Cognitive Decline in Alzheimer's Disease Patients | Zendy

Konstantinos Stellos | Zendy; Victoria Panagiota | Zendy; A.J. ban Der Kogel | Zendy; Thomas Leyhe | Zendy; Meinrad Gawaz | Zendy; Christoph Laske | Zendy

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Predictive Value of Platelet Activation for the Rate of Cognitive Decline in Alzheimer's Disease Patients

Author(s) -

Konstantinos Stellos,

Victoria Panagiota,

A.J. ban Der Kogel,

Thomas Leyhe,

Meinrad Gawaz,

Christoph Laske

Publication year - 2010

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2010.140

Subject(s) - platelet activation , cognitive decline , platelet , biomarker , dementia , medicine , p selectin , disease , cognition , alzheimer's disease , oncology , psychology , psychiatry , biology , biochemistry

Vascular risk factors contribute to the progression of dementia in Alzheimer's disease (AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb–IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients.

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