Correspondence between Altered Functional and Structural Connectivity in the Contralesional Sensorimotor Cortex after Unilateral Stroke in Rats: A Combined Resting-State Functional MRI and Manganese-Enhanced MRI Study | Zendy

Maurits PA van Meer | Zendy; Kajo van der Marel | Zendy; Willem M. Otte | Zendy; Jan Willem Berkelbach van der Sprenkel | Zendy; Rick M. Dijkhuizen | Zendy

Open Access

Correspondence between Altered Functional and Structural Connectivity in the Contralesional Sensorimotor Cortex after Unilateral Stroke in Rats: A Combined Resting-State Functional MRI and Manganese-Enhanced MRI Study

Author(s) -

Maurits PA van Meer,

Kajo van der Marel,

Willem M. Otte,

Jan Willem Berkelbach van der Sprenkel,

Rick M. Dijkhuizen

Publication year - 2010

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2010.124

Subject(s) - functional magnetic resonance imaging , neuroscience , sensorimotor cortex , cortex (anatomy) , motor cortex , functional connectivity , resting state fmri , primary motor cortex , stroke (engine) , psychology , magnetic resonance imaging , functional imaging , medicine , radiology , stimulation , engineering , mechanical engineering

This study shows a significant correlation between functional connectivity, as measured with resting-state functional magnetic resonance imaging (MRI), and neuroanatomical connectivity, as measured with manganese-enhanced MRI, in rats at 10 weeks after unilateral stroke and in age-matched controls. Reduced interhemispheric functional connectivity between the contralesional primary motor cortex (M1) and ipsilesional sensorimotor cortical regions was accompanied by a decrease in transcallosal manganese transfer from contralesional M1 to the ipsilesional sensorimotor cortex after a large unilateral stroke. Increased intrahemispheric functional connectivity in the contralesional sensorimotor cortex was associated with locally enhanced neuroanatomical tracer uptake, which underlines the strong link between functional and structural reorganization of neuronal networks after stroke.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research