Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke | Zendy

Barry W. McColl | Zendy; Nicola J. Rose | Zendy; Fiona H Robson | Zendy; Nancy J. Rothwell | Zendy; Catherine B. Lawrence | Zendy

Open Access

Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke

Author(s) -

Barry W. McColl,

Nicola J. Rose,

Fiona H Robson,

Nancy J. Rothwell,

Catherine B. Lawrence

Publication year - 2009

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2009.217

Subject(s) - medicine , stroke (engine) , blood–brain barrier , brain ischemia , leptin , ischemia , cardiology , endocrinology , obesity , central nervous system , mechanical engineering , engineering

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke.

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