Open AccessIn vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–Brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study
Author(s) -
Hao-Li Liu,
YauYau Wai,
Po-Hong Hsu,
Lee-Ang Lyu,
Jiashin Wu,
ChiaRui Shen,
JinChung Chen,
TzuChen Yen,
JiunJie Wang
Publication year - 2009
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.2009.179
Subject(s) - sonication , blood–brain barrier , ultrasound , focused ultrasound , magnetic resonance imaging , in vivo , infiltration (hvac) , medicine , permeability (electromagnetism) , pathology , biomedical engineering , central nervous system , materials science , chemistry , radiology , biology , biochemistry , microbiology and biotechnology , membrane , composite material
Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood-brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters.
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