Open AccessTotal Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study
Author(s) -
Mariëlle M.F. Poels,
M. Arfan Ikram,
Meike W. Vernooij,
Gabriël P. Krestin,
Albert Hofman,
Wiro J Messen,
Aad van der Lugt,
Monique M.B. Breteler
Publication year - 2008
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.2008.62
Subject(s) - rotterdam study , cerebral blood flow , cognition , brain size , magnetic resonance imaging , atrophy , cerebral perfusion pressure , medicine , population , psychology , blood flow , association (psychology) , perfusion scanning , neuroscience , cardiology , perfusion , radiology , environmental health , psychotherapist
Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.
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