Expression of Cadherin Superfamily Genes in Brain Vascular Development | Zendy

Krishna Kumar | Zendy; Christoph Redies | Zendy

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Expression of Cadherin Superfamily Genes in Brain Vascular Development

Author(s) -

Krishna Kumar,

Christoph Redies

Publication year - 2008

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.2008.123

Subject(s) - superfamily , cadherin , gene , biology , microbiology and biotechnology , computational biology , neuroscience , genetics , cell

Cadherins are Ca 2+ -dependent cell adhesion molecules that are important in vertebrate nervous system development. We identified seven members of the cadherin superfamily (cadherin-4, cadherin-5, cadherin-6, cadherin-6, cadherin-11, protocadherin-1, and protocadherin-17) and an intracellular binding partner of δ-protocadherins, protein phosphatase 1α, as novel markers for developing blood vessels in the ferret brain. Some of the cadherin molecules are restricted to specific brain regions or a subset of blood vessels. The expression levels show a peak during perinatal vascular development. Our results suggest that multiple cadherins, which are also involved in neurogenesis, are regulators of angiogenesis in developing vertebrate brain.

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