Change in Cerebral Blood Flow Velocity with Onset of EEG Silence during Inhalation Anesthesia in Humans: Evidence of Flow-Metabolism Coupling? | Zendy

Arthur M. Lam | Zendy; Basil Matta | Zendy; Teresa S. Mayberg | Zendy; Stephan Strebel | Zendy

Open Access

Change in Cerebral Blood Flow Velocity with Onset of EEG Silence during Inhalation Anesthesia in Humans: Evidence of Flow-Metabolism Coupling?

Author(s) -

Arthur M. Lam,

Basil Matta,

Teresa S. Mayberg,

Stephan Strebel

Publication year - 1995

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1995.88

Subject(s) - isoflurane , normocapnia , anesthesia , cerebral blood flow , inhalation , electroencephalography , blood flow , desflurane , medicine , sevoflurane , cardiology , hypercapnia , psychiatry , acidosis

In eight subjects anesthetized with moderate to high doses of inhalation anesthetics (isoflurane or desflurane) during normocapnia, the onset of electrical silence in EEG was associated with a sudden reduction of blood flow velocity monitored from the middle cerebral artery. The magnitude of this reduction was 38 ± 11% (mean ± SD; range 24–44%). The change in EEG always preceded the change in flow velocity by 5–7 s. These observations suggest that some flow–metabolism coupling mechanism is preserved during inhalation anesthesia in humans.

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