Photic Stimulation Study of Changing the Arterial Partial Pressure Level of Carbon Dioxide | Zendy

Eku Shimosegawa | Zendy; Iwao Kanno | Zendy; Jun Hatazawa | Zendy; Hideaki Fujita | Zendy; Hidehiro Iida | Zendy; Shuichi Miura | Zendy; Matsutarou Murakami | Zendy; A Inugami | Zendy; Toshihide Ogawa | Zendy; Hiroshi Itoh | Zendy; Toshio Okudera | Zendy; Kazuo Uemura | Zendy

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Photic Stimulation Study of Changing the Arterial Partial Pressure Level of Carbon Dioxide

Author(s) -

Eku Shimosegawa,

Iwao Kanno,

Jun Hatazawa,

Hideaki Fujita,

Hidehiro Iida,

Shuichi Miura,

Matsutarou Murakami,

A Inugami,

Toshihide Ogawa,

Hiroshi Itoh,

Toshio Okudera,

Kazuo Uemura

Publication year - 1995

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1995.12

Subject(s) - normocapnia , hypocapnia , hypercapnia , cerebral blood flow , anesthesia , stimulation , medicine , photic stimulation , cardiology , psychology , neuroscience , acidosis , visual perception , perception

To investigate the effect of the level of baseline cerebral blood flow (CBF) on local CBF augmentation by activation, we have used positron emission tomography to measure regional CBF (rCBF) in 12 normal volunteers with and without photic stimulation during hypocapnia, normocapnia, and hypercapnia. The increase in rCBF in the primary visual cortex by photic stimulation was 10.8 ± 3.1, 18.6 ± 9.3, and 19.5 ± 6.1 ml 100 ml −1 min −1 in hypo-, normo-, and hypercapnia, respectively. The increase was significantly smaller in hypocapnia than in normocapnia ( p < 0.005). The fractional CBF increase caused by the photic stimulation was the same in all breathing conditions. This result indicates that the magnitude of the CBF increase induced by neuronal activity correlates proportionally with the level of baseline CBF.

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