Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus | Zendy

Thomas Beck | Zendy; Dan Lindholm | Zendy; Eero Ċastrén | Zendy; Andreas Wree | Zendy

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Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

Author(s) -

Thomas Beck,

Dan Lindholm,

Eero Ċastrén,

Andreas Wree

Publication year - 1994

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1994.86

Subject(s) - neuroprotection , hippocampus , neurotrophic factors , brain derived neurotrophic factor , tropomyosin receptor kinase b , neuroscience , ischemia , neurotrophin , medicine , forebrain , receptor , central nervous system , biology

The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB – receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.

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