Angiotensin IV Reverses the Acute Cerebral Blood Flow Reduction after Experimental Subarachnoid Hemorrhage in the Rat | Zendy

Liisa Näveri | Zendy; Christer Strömberg | Zendy; Juan M. Saavedra | Zendy

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Angiotensin IV Reverses the Acute Cerebral Blood Flow Reduction after Experimental Subarachnoid Hemorrhage in the Rat

Author(s) -

Liisa Näveri,

Christer Strömberg,

Juan M. Saavedra

Publication year - 1994

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1994.143

Subject(s) - subarachnoid hemorrhage , angiotensin ii , cerebral blood flow , medicine , saline , nitric oxide , laser doppler velocimetry , nitric oxide synthase , in vivo , endocrinology , antagonist , renin–angiotensin system , anesthesia , blood flow , chemistry , blood pressure , biology , receptor , microbiology and biotechnology

The effect of angiotensin (ANG) IV on CBF after experimental subarachnoid hemorrhage (SAH) was studied in rats using laser–Doppler flowmetry. ANG IV (1 μg/kg/min i.v.) or saline treatments were started 20 min after SAH. ANG IV increased CBF (from 45 to 84% of baseline) by 60 min. In the saline group, CBF remained low (51%). Pretreatment with the specific ANG II antagonist Sar 1 , Ile 8 -ANG II did not antagonize ANG IV. Determination of nitric oxide synthase (NOS) activity in vitro or inhibition of NOS in vivo did not support a role for NO in the action of ANG IV.

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