Local Cerebral Blood Flow in Rats with Congenital Hydrocephalus

Local cerebral blood flow (LCBF) has been measured by [ 14 C]iodoantipyrine quantitative autoradiography in H-Tx rats with inherited congenital hydrocephalus at 10, 21, and 30 days after birth. LCBF at 10 days was uniformly low in all ten brain regions studied and not significantly different between hydrocephalic and age-matched control rats. By 21 days LCBF had increased significantly in control rats. LCBF was significantly lower (<69%) in the hydrocephalics in all cortical regions and in the inferior colliculus LCBF at both 21 and 30 days. The cerebellar cortex, pons, and caudate were not significantly affected. At 30 days LCBF ranged from 55 to 115 ml 100 g −1 min −1 for hydrocephalics and from 100 to 183 ml 100 g −1 min −1 for controls.