Open AccessDecrease in Human Striatal Dopamine D2 Receptor Density with Age: A PET Study with [11C]Raclopride
Author(s) -
Juha O. Rinne,
Jarmo Hietala,
Ulla Ruotsalainen,
Erkki Säkö,
A. Laihinen,
Kjell Någren,
Pertti Lehikoinen,
Vesa Oikonen,
Erkka Syvälahti
Publication year - 1993
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.1993.39
Subject(s) - raclopride , radioligand , dopaminergic , medicine , endocrinology , dopamine receptor , receptor , dopamine , dissociation constant , positron emission tomography , binding potential , dopamine receptor d2 , chemistry , striatum , human brain , psychology , neuroscience , nuclear medicine
The effect of age on human striatal dopamine D 2 receptors was investigated with positron emission tomography (PET) using [ 11 C]raclopride as a radioligand. Twenty-one healthy volunteers aged from 20 to 81 years were studied. An equilibrium method was applied and two separate PET scans with different specific activities of [ 11 C]raclopride were performed. The maximal number of receptors ( B max ) and their dissociation constant ( K d ) were calculated using Scatchard analysis. There was an age-dependent decline in the B max ( r = 0.49; p = 0.02) of striatal D 2 receptors while the K d remained unchanged. The results show that there is an age-related loss of striatal D 2 receptors, which, together with other changes in the brain nigrostriatal dopaminergic system, may contribute to extrapyramidal symptoms associated with aging.
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