DFMO Reduces Cortical Infarct Volume after Middle Cerebral Artery Occlusion in the Rat | Zendy

Cheryl A. Muszynski | Zendy; Claudia S. Robertson | Zendy; J. Clay Goodman | Zendy; Charles M. Henley | Zendy

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DFMO Reduces Cortical Infarct Volume after Middle Cerebral Artery Occlusion in the Rat

Author(s) -

Cheryl A. Muszynski,

Claudia S. Robertson,

J. Clay Goodman,

Charles M. Henley

Publication year - 1993

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1993.131

Subject(s) - ornithine decarboxylase , ischemia , polyamine , medicine , middle cerebral artery , stroke (engine) , infarction , striatum , anesthesia , endocrinology , pharmacology , chemistry , enzyme , biochemistry , dopamine , myocardial infarction , mechanical engineering , engineering

Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is induced in ischemic tissue and may mediate vasogenic edema and delayed neuronal death. We determined the effects of α-difluoromethylornithine (DFMO), a specific inhibitor of ODC, on infarct size and ODC activity in a rat model of transient focal ischemia. DFMO blocked the ischemia-induced increase in ODC and significantly reduced infarct volumes by 57–45%, depending upon the treatment regimen. These studies suggest that polyamine metabolism plays a role in the development of cerebral infarction after focal ischemia and that DFMO may be useful in limiting injury after a stroke.

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