Dynamic High-Resolution MR Imaging of Brain Deoxygenation during Transient Anoxia in the Anesthetized Rat | Zendy

F. X. Prielmeier | Zendy; KlausDietmar Merboldt | Zendy; Wolfgang Hänicke | Zendy; Jens Frahm | Zendy

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Dynamic High-Resolution MR Imaging of Brain Deoxygenation during Transient Anoxia in the Anesthetized Rat

Author(s) -

F. X. Prielmeier,

KlausDietmar Merboldt,

Wolfgang Hänicke,

Jens Frahm

Publication year - 1993

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1993.111

Subject(s) - magnetic resonance imaging , temporal resolution , oxygenation , nuclear magnetic resonance , blood oxygenation , deoxygenation , nuclear medicine , signal (programming language) , functional magnetic resonance imaging , medicine , neuroscience , chemistry , anesthesia , physics , radiology , biology , computer science , biochemistry , quantum mechanics , catalysis , programming language

Transient alterations in brain oxygenation during 60-s periods of anoxia were visualized at high spatial resolution (voxel size ≤ 0.15 μl) with the use of serial long echo time FLASH (fast low-angle shot) magnetic resonance images (measuring time ≥ 6 s) of halothaneanesthetized rats in vivo. Difference images from normoxia and anoxia exploit the signal decrease associated with increased levels of paramagnetic deoxyhemoglobin in the arterial and venous blood pool. Insights into the spatial heterogeneity of oxygen deprivation are complemented by physiologic information from the time course of pertinent signal changes in different regions of the brain.

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