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We studied the effects of N G -monomethyl-l-arginine (l-NMMA) and N ω -nitro-l-arginine (l-NNA) on the selective ATP and adenosine-induced enhancement of intratumoral blood flow in rats measured by the hydrogen clearance method. Both adenosine and ATP produced a selective enhancement of the intratumoral blood flow. Neither l-NMMA nor l-NNA had a significant effect on either the CBF or the intratumoral blood flow. Adenosine-induced enhancement was not inhibited by l-NMMA or l-NNA. On the other hand, the ATP-induced enhancement was totally inhibited by both l-NMMA and l-NNA. The inhibitory action of l-NMMA against ATP was blocked by l-arginine, but not by d-arginine. It is suggested that the ATP-induced increase of intratumoral blood flow is evoked by nitric oxide synthesized from the endothelium of the intratumoral blood vessels.

Effects of l-NMMA and l-NNA on the Selective ATP-Induced Enhancement of Intratumoral Blood Flow