Open AccessEffects of l-NMMA and l-NNA on the Selective ATP-Induced Enhancement of Intratumoral Blood Flow
Author(s) -
Yoshihiro Natori,
M. Moriguchi,
Sumire Fujiwara,
Iwao Takeshita,
M. Fukui,
Toru Iwaki,
Hideo Kanaide
Publication year - 1992
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.1992.15
Subject(s) - nitric oxide , arginine , omega n methylarginine , adenosine , blood flow , nitroarginine , endothelium derived relaxing factor , chemistry , blood vessel , pharmacology , nitric oxide synthase , endocrinology , medicine , biochemistry , amino acid
We studied the effects of N G -monomethyl-l-arginine (l-NMMA) and N ω -nitro-l-arginine (l-NNA) on the selective ATP and adenosine-induced enhancement of intratumoral blood flow in rats measured by the hydrogen clearance method. Both adenosine and ATP produced a selective enhancement of the intratumoral blood flow. Neither l-NMMA nor l-NNA had a significant effect on either the CBF or the intratumoral blood flow. Adenosine-induced enhancement was not inhibited by l-NMMA or l-NNA. On the other hand, the ATP-induced enhancement was totally inhibited by both l-NMMA and l-NNA. The inhibitory action of l-NMMA against ATP was blocked by l-arginine, but not by d-arginine. It is suggested that the ATP-induced increase of intratumoral blood flow is evoked by nitric oxide synthesized from the endothelium of the intratumoral blood vessels.
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