Plasma L-[18F]6-Fluorodopa Input Function: A Simplified Method | Zendy

Grace Chan | Zendy; Kaitlin Morrison | Zendy; James E. Holden | Zendy; Thomas J. Ruth | Zendy

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Plasma L-[¹⁸F]6-Fluorodopa Input Function: A Simplified Method

Author(s) -

Grace Chan,

Kaitlin Morrison,

James E. Holden,

Thomas J. Ruth

Publication year - 1992

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1992.121

Subject(s) - carbidopa , nuclear medicine , positron emission tomography , plasma , chemistry , medicine , physics , levodopa , nuclear physics , disease , parkinson's disease

This article describes a simplified method for the determination of the L-[18F]6-fluorodopa (FDOPA) fraction time course that takes advantage of the strong correlation between the radioactivity ratio (metabolites/FDOPA) and time. Serial arterial blood samples are collected for assay of plasma total radioactivities following an intravenous injection of FDOPA into carbidopapretreated subjects. In addition, a single plasma sample, collected late in the study and analyzed for FDOPA fraction, is sufficient to determine accurately the time course of the FDOPA concentration in plasma. The validated straight-line method greatly simplifies blood analysis for routine positron emission tomography FDOPA studies.

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