Reduction of Infarct Volume by Magnesium after Middle Cerebral Artery Occlusion in Rats | Zendy

Yoshio Izumi | Zendy; Simon Roussel | Zendy; Elisabeth Pinard | Zendy; Jacques Seylaz | Zendy

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Reduction of Infarct Volume by Magnesium after Middle Cerebral Artery Occlusion in Rats

Author(s) -

Yoshio Izumi,

Simon Roussel,

Elisabeth Pinard,

Jacques Seylaz

Publication year - 1991

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1991.170

Subject(s) - middle cerebral artery , neocortex , medicine , ischemia , neuroprotection , occlusion , perfusion , anesthesia , cardiology , calcium , psychiatry

The effects of magnesium, an endogenous inhibitor of calcium entry into neurons, upon ischemic brain damage were investigated using a well-characterized model of focal cerebral ischemia in rats. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride transcardiac perfusion 48 h after middle cerebral artery (MCA) occlusion. The area of ischemic damage was quantified by image analysis in coronal sections taken every 0.5 mm. MgCl 2 (1 mmol/kg) was injected intraperitoneally just after MCA occlusion and again 1 h later. Posttreatment with MgCl 2 (16 control and 16 treated rats) significantly reduced the cortical infarct volume. Compensation for the hyperglycemic effect of MgCl 2 with insulin (17 rats) further reduced the infarct volume in the neocortex. No systemic effects of either treatment could account for the observed neuroprotection.

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