PAF Antagonist Ginkgolide B Reduces Postischemic Neuronal Damage in Rat Brain Hippocampus | Zendy

Heike Oberpichler | Zendy; Dirk Sauer | Zendy; C Rossberg | Zendy; Hans-Dieter Mennel | Zendy; Josef Krieglstein | Zendy

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PAF Antagonist Ginkgolide B Reduces Postischemic Neuronal Damage in Rat Brain Hippocampus

Author(s) -

Heike Oberpichler,

Dirk Sauer,

C Rossberg,

Hans-Dieter Mennel,

Josef Krieglstein

Publication year - 1990

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1990.17

Subject(s) - antagonist , hippocampus , platelet activating factor , pharmacology , forebrain , ischemia , antagonism , neuroscience , central nervous system , medicine , chemistry , anesthesia , biology , receptor

We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.

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