Open AccessCombination of Dynamic and Integral Methods for Generating Reproducible Functional CBF Images
Author(s) -
Adriaan A. Lammertsma,
Vincent J. Cunningham,
MariePierre Deiber,
J. D. Heather,
P Bloomfield,
John G. Nutt,
R. S. J. Frackowiak,
Terry Jones
Publication year - 1990
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1038/jcbfm.1990.121
Subject(s) - reproducibility , dispersion (optics) , positron emission tomography , nuclear medicine , pixel , biomedical engineering , computer science , biological system , mathematics , physics , medicine , artificial intelligence , optics , statistics , biology
A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
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