Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage | Zendy

Lars Edvinsson | Zendy; T. J. Delgado-Zygmunt | Zendy; Rolf Ekman | Zendy; I. Jansen | Zendy; N-Aa Svendgaard | Zendy; Rolf Uddman | Zendy

Open Access

Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage

Author(s) -

Lars Edvinsson,

T. J. Delgado-Zygmunt,

Rolf Ekman,

I. Jansen,

N-Aa Svendgaard,

Rolf Uddman

Publication year - 1990

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1990.111

Subject(s) - calcitonin gene related peptide , basilar artery , subarachnoid hemorrhage , vasospasm , medicine , substance p , postsynaptic potential , vasoconstriction , pathophysiology , calcitonin , endocrinology , denervation , cerebral arteries , anesthesia , chemistry , neuropeptide , receptor

The involvement of perivascular sensory fibers containing substance P (SP) and calcitonin gene-related peptide (CGRP) in the events occurring in conjunction with subarachnoid hemorrhage (SAH) has been studied in a rat model. Two days after blood injection, the time point at which maximum vasoconstriction is occurring in this model, immunocytochemistry and radioimmunoassay showed a reduction in SP- and CGRP-like immunoreactivity (LI). The quantitative measurements revealed a significant 50% reduction of CGRP-LI and a slight reduction of SP-LI in SAH as compared to controls. This partial reduction in neurotransmitter content (denervation) caused no change in the sensitivity of the rat basilar artery to SP or CGRP as studied using a sensitive in vitro method. However, the maximum relaxant response to CGRP was increased from 52 to 81% ( p < 0.05), while there was no change in the maximum SP-induced relaxations. It is suggested that not only a pre-, but also a postsynaptic modulation of perivascular sensory fibers may occur in experimental SAH.

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