Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex | Zendy

Nobumitsu Shimada | Zendy; Rudolf Graf | Zendy; Gerd Rosner | Zendy; Akatsuki Wakayama | Zendy; Charles P. George | Zendy; Wolf-Dieter Heiß | Zendy

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Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex

Author(s) -

Nobumitsu Shimada,

Rudolf Graf,

Gerd Rosner,

Akatsuki Wakayama,

Charles P. George,

Wolf-Dieter Heiß

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.86

Subject(s) - microdialysis , penumbra , extracellular , glutamate receptor , cerebral blood flow , neurotoxicity , cats , ischemia , cortex (anatomy) , auditory cortex , cerebral cortex , extracellular fluid , neuroscience , anesthesia , electrocorticography , glutamic acid , medicine , chemistry , biology , biochemistry , electroencephalography , toxicity , amino acid , receptor

Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of anesthetized cats during global ischemia of various severities. A threshold-type relationship was observed between extracellular Glu and CBF: Glu increased at CBF levels below about 20 ml/100 g/min. The Glu increase was related to the impairment of AEPs. The results suggest that Glu neurotoxicity is an important factor for ischemic neuronal injury even in penumbra.

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