Estimation of Local Cerebral Protein Synthesis Rates with L-[1-11C]Leucine and PET: Methods, Model, and Results in Animals and Humans | Zendy

Randall A. Hawkins | Zendy; SungCheng Huang | Zendy; Jorge R. Barrio | Zendy; R.E. Keen | Zendy; Dagan Feng | Zendy; John C. Mazziotta | Zendy; Michael E. Phelps | Zendy

Open Access

Estimation of Local Cerebral Protein Synthesis Rates with L-[1-¹¹C]Leucine and PET: Methods, Model, and Results in Animals and Humans

Author(s) -

Randall A. Hawkins,

SungCheng Huang,

Jorge R. Barrio,

R.E. Keen,

Dagan Feng,

John C. Mazziotta,

Michael E. Phelps

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.68

Subject(s) - compartment (ship) , positron emission tomography , nuclear medicine , metabolite , leucine , biology , biochemistry , medicine , amino acid , oceanography , geology

We have estimated the cerebral protein synthesis rates (CPSR) in a series of normal human volunteers and monkeys using L-[1-11C]leucine and positron emission tomography (PET) using a three-compartment model. The model structure, consisting of a tissue precursor, metabolite, and protein compartment, was validated with biochemical assay data obtained in rat studies. The CPSR values estimated in human hemispheres of about 0.5 nmol/min/g agree well with hemispheric estimates in monkeys. The sampling requirements (input function and scanning sequence) for accurate estimates of model parameters were investigated in a series of computer simulation studies.

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