Effects of Neuropeptide Y and Calcitonin Gene-Related Peptide on Local Cerebral Blood Flow in Rat Striatum | Zendy

Yoshio Suzuki | Zendy; Shin’ichi Satoh | Zendy; Ichiro Ikegaki | Zendy; Tomohisa Okada | Zendy; Masato Shibuya | Zendy; Kenichiro Sugita | Zendy; Toshio Asano | Zendy

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Effects of Neuropeptide Y and Calcitonin Gene-Related Peptide on Local Cerebral Blood Flow in Rat Striatum

Author(s) -

Yoshio Suzuki,

Shin’ichi Satoh,

Ichiro Ikegaki,

Tomohisa Okada,

Masato Shibuya,

Kenichiro Sugita,

Toshio Asano

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.44

Subject(s) - calcitonin gene related peptide , endocrinology , neuropeptide y receptor , medicine , neuropeptide , cerebral blood flow , striatum , calcitonin , bolus (digestion) , blood flow , chemistry , dopamine , receptor

The effects of neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) on local cerebral blood flow (LCBF) were studied in vivo in rat striatum. Administration of 1 and 5 nmol NPY as a bolus into the internal carotid artery caused a dose-dependent decrease in the ipsilateral striatal LCBF. This decrease developed slowly and persisted for at least 2 h, without affecting mean blood pressure. In contrast, CGRP, at a concentration of 10 pmol, increased striatal LCBF by about 30%, and the duration of the increase was about 1 h. However, at higher doses of CGRP no increase in LCBF was observed. These results suggest that NPY and CGRP released from nerve fibers innervating blood vessels can function as long-acting modulators of CBF.

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