Effects of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Blood Flow in the Rat | Zendy

Gilles Bonvento | Zendy; P. Lacombe | Zendy; Jacques Seylaz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Blood Flow in the Rat

Author(s) -

Gilles Bonvento,

P. Lacombe,

Jacques Seylaz

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.41

Subject(s) - dorsal raphe nucleus , interpeduncular nucleus , raphe nuclei , serotonergic cell groups , stimulation , median raphe nucleus , neuroscience , nucleus , cerebral blood flow , nucleus accumbens , chemistry , serotonergic , central nervous system , serotonin , medicine , anesthesia , biology , midbrain , receptor

We have studied the effects of electrical stimulation of the dorsal raphe nucleus on local cerebral blood flow (LCBF), as assessed by the quantitative [ 14 C]-iodoantipyrine autoradiographic technique. Stimulation of the dorsal raphe nucleus in the α-chloralose anesthetized rat caused a significant decrease in LCBF, ranging from – 13 to – 26% in 24 brain structures out of 33 investigated. The most pronounced decreases (– 23 to – 26%) were observed in the accumbens, amygdaloid, interpeduncular nuclei and in the median raphe nucleus, limbic system relays. The decreases also concerned cortical regions and the extrapyramidal system. These results indicate that activation of ascending serotonergic system produces a vasoconstriction and that the dorsal raphe nucleus has a widespread modulatory influence on the cerebral circulation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research