Effect of Thyrotropin-Releasing Hormone on Cerebral Blood Flow in Conscious Rat | Zendy

Yasushi Kondoh | Zendy; Shigenori Mizusawa | Zendy; Matsutaro Murakami | Zendy; Ken Nagata | Zendy; Hiroshi Sasaki | Zendy; Hiroyuki Nakamichi | Zendy; Katsuhiro Watanabe | Zendy; Kazuo Uemura | Zendy

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Effect of Thyrotropin-Releasing Hormone on Cerebral Blood Flow in Conscious Rat

Author(s) -

Yasushi Kondoh,

Shigenori Mizusawa,

Matsutaro Murakami,

Ken Nagata,

Hiroshi Sasaki,

Hiroyuki Nakamichi,

Katsuhiro Watanabe,

Kazuo Uemura

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.29

Subject(s) - thyrotropin releasing hormone , medicine , endocrinology , cerebral blood flow , hormone , white matter , chemistry , magnetic resonance imaging , radiology

The effect of thyrotropin-releasing hormone (TRH) was studied on local CBF (LCBF) in normal conscious rats. LCBF was measured by the autoradiographic [ 14 C]iodoantipyrine method 5 min after TRH (5 mg/kg, i.v.) administration. TRH significantly increased LCBF in 22 of 33 brain regions. This increase of LCBF exceeded 100% of the control values in the cerebral cortices, whereas there was no significant increase in white matter or in some gray matter structures. The increase of CBF following TRH administration was abolished by pretreatment with indomethacin (5 mg/kg, i.v.). The mechanisms underlying the increase of CBF following TRH administration are discussed in relation to prostaglandin metabolism.

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