Serotonin Potentiates Noradrenaline-Induced Vasoconstriction through 5-HT1-Type Receptors in Guinea Pig Basilar Artery | Zendy

JingYu Chang | Zendy; Christer Owman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Serotonin Potentiates Noradrenaline-Induced Vasoconstriction through 5-HT₁-Type Receptors in Guinea Pig Basilar Artery

Author(s) -

JingYu Chang,

Christer Owman

Publication year - 1989

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1989.100

Subject(s) - methysergide , ketanserin , basilar artery , serotonin , vasoconstriction , medicine , endocrinology , contraction (grammar) , stimulation , 5 ht receptor , guinea pig , receptor , long term potentiation , chemistry

Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of guinea pig. A low concentration of 5-HT, which in itself has little or no constrictive effect, potentiated the weak contraction of NE by almost 300%. The amplification was antagonized by methiothepin, but not by ketanserin, and it could be mimicked by methysergide. The marked potentiation is thus probably associated with the 5-HT1-like receptors, which earlier have been found to mediate the direct vasoconstrictive action of 5-HT in this vessel preparation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research