Elevated Cerebellar Glucose Metabolism in Microvascular White Matter Disease: Normal Aging and Alzheimer's Disease | Zendy

Allan Klinger | Zendy; Mony J. de Leon | Zendy; Ajax E. George | Zendy; Jeffrey D. Miller | Zendy; Alfred P. Wolf | Zendy

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Elevated Cerebellar Glucose Metabolism in Microvascular White Matter Disease: Normal Aging and Alzheimer's Disease

Author(s) -

Allan Klinger,

Mony J. de Leon,

Ajax E. George,

Jeffrey D. Miller,

Alfred P. Wolf

Publication year - 1988

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1988.80

Subject(s) - positron emission tomography , white matter , medicine , alzheimer's disease , cerebellum , disease , degenerative disease , central nervous system disease , nuclear medicine , pathology , radiology , magnetic resonance imaging

Young normal, elderly, and clinically diagnosed Alzheimer disease subjects who had undergone positron emission tomography (PET) and computed tomography (CT) examinations were studied to determine the effect of periventricular white matter lesions on cerebellar glucose metabolic rates. PET-determined cerebellar metabolic rates were elevated in subjects with periventricular white matter lesions. These results suggest the cautious use of cortical-to-cerebellar ratios in future PET or single-photon-emission CT (SPECT) studies.

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