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The aim of this study was to test the effect of adenosine and four of its analogues, 5'-( N-ethyl)carboxamidoadenosine (NECA), 2-chloroadenosine (2-CADO), L-phenylisopropyladenosine (L-PIA), and N 6 -cyclohexyladenosine (CHA), on prostaglandin (PG) F 2α -constricted pig basilar arteries, and from their rank order of potency determine the receptor type involved, The order of potency for the relaxation of the PGF 2α  constriction was NECA &gt; adenosine, 2-CADO &gt; L-PIA &gt; CHA, which is in keeping with the A 2  receptor subtype, The study also investigated the effects of a known adenosine antagonist, namely, the xanthine derivative 8-phenyltheophylline, which at concentrations having no intrinsic effect (10 −8  and 10 −7  M) produced a significant shift to the right only for the NECA dose-response curve.

Effects of Adenosine and its Analogues on Porcine Basilar Arteries: Are Only A2 Receptors Involved?

Effects of Adenosine and its Analogues on Porcine Basilar Arteries: Are Only A₂ Receptors Involved?