Effects of Adenosine and its Analogues on Porcine Basilar Arteries: Are Only A2 Receptors Involved? | Zendy

Douglas E. McBean | Zendy; A. M. Harper | Zendy; Karl Asmund Rudolphi | Zendy

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Effects of Adenosine and its Analogues on Porcine Basilar Arteries: Are Only A₂ Receptors Involved?

Author(s) -

Douglas E. McBean,

A. M. Harper,

Karl Asmund Rudolphi

Publication year - 1988

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1988.6

Subject(s) - adenosine , adenosine receptor , potency , medicine , chemistry , endocrinology , basilar artery , antagonist , receptor , adenosine a1 receptor , pharmacology , agonist , in vitro , biochemistry

The aim of this study was to test the effect of adenosine and four of its analogues, 5'-( N-ethyl)carboxamidoadenosine (NECA), 2-chloroadenosine (2-CADO), L-phenylisopropyladenosine (L-PIA), and N 6 -cyclohexyladenosine (CHA), on prostaglandin (PG) F 2α -constricted pig basilar arteries, and from their rank order of potency determine the receptor type involved, The order of potency for the relaxation of the PGF 2α constriction was NECA > adenosine, 2-CADO > L-PIA > CHA, which is in keeping with the A 2 receptor subtype, The study also investigated the effects of a known adenosine antagonist, namely, the xanthine derivative 8-phenyltheophylline, which at concentrations having no intrinsic effect (10 −8 and 10 −7 M) produced a significant shift to the right only for the NECA dose-response curve.

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