Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat | Zendy

Emin Özyurt | Zendy; David I. Graham | Zendy; G.N. Woodruff | Zendy; James McCulloch | Zendy

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Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

Author(s) -

Emin Özyurt,

David I. Graham,

G.N. Woodruff,

James McCulloch

Publication year - 1988

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1038/jcbfm.1988.18

Subject(s) - nmda receptor , cats , glutamate receptor , ischemia , anesthesia , middle cerebral artery , medicine , cerebral blood flow , antagonist , brain damage , dizocilpine , receptor

The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery and the animal were killed 6 h later. The amount of early ischemic damage was assessed in coronal sections at 16 predetermined stereotactic planes. Pretreatment with MK-801 (5 mg/kg, i.v.), 30 min before occlusion of the middle cerebral artery significantly reduced the volume of ischemic damage (from 32.7 +/- 4.0% of the cerebral hemisphere in vehicle-treated cats to 16.2 +/- 4.5% in MK-801-treated cats). NMDA receptor antagonists that penetrate the blood-brain barrier, such as MK-801, merit further study as protective agents against ischemic brain damage.

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